Deutscher Forschungsverbund Neuropathischer Schmerz DFNS: DFNS Publikationen

2012

Krumova EK, Zeller M, Westermann A, Maier C (2012) Lidocaine patch (5%) produces a selective, but incomplete block of Ad and C fibers.Pain 153(2):273-80
Westermann A, Krumova EK, Pennekamp W, Horch C, Baron R, Maier C (2012) Different underlying pain mechanisms despite identical pain characteristics: A case report of a patient with spinal cord injury. Pain Mar 21. [Epub ahead of print]

2011

Binder A, May D, Baron R, Maier C, Tölle TR, Treede R.-D, Berthele A, Faltraco F, Flor H, Gierthmühlen J, Haenisch S, Huge V, Magerl W, Maihöfner C, Richter H, Rolke R, Scherens A, Sommer C, Ufer M, Wasner G, Zhou J, Cascorbi I (2011) Transient Receptor Potential channel polymorphisms are associated with the somatosensory function in neuropathic pain patients. PLoS ONE 6(3): e17387
Geber C, Baumgärtner U, Fechir M, Vogt T, Birklein F, Treede RD (2011) Comparison of LEP and QST and their contribution to standard sensory diagnostic assessment of spinal lesions: a pilot study. Neurol Sci. 32(3):401-10
Geber C, Klein T, Azad S, Birklein F, Gierthmühlen J, Huge V, Lauchart M, Nitzsche D, Stengel M, Valet M, Baron R, Maier C, Tölle T, Treede RD (2011) Test-retest and interobserver reliability of quantitative sensory testing according to the protocol of the German Research Network on Neuropathic Pain (DFNS): A multi-centre study. Pain 152(3):548-56
Gierthmühlen J, Maier C, Baron R, Tölle T, Treede RD, Birbaumer N, Huge V, Koroschetz J, Krumova EK, Lauchart M, Maihöfner C, Richter H, Westermann A (2011) Sensory signs in complex regional pain syndrome and peripheral nerve injury. Pain 153(4):765-774
Hopfner F, Schormair B, Knauf F, Berthele A, Tölle TR, Baron R, Maier C, Treede RD, Binder A, Sommer C, Maihöfner C, Kunz W, Zimprich F, Heemann U, Pfeufer A, Näbauer M, Kääb S, Nowak B, Gieger C, Lichtner P, Trenkwalder C, Oexle K, Winkelmann J (2011) Novel SCARB2 mutation in action myoclonus-renal failure syndrome and evaluation of SCARB2 mutations in isolated AMRF features. BMC Neurol. 11:134.
Lenz M, Höffken O, Stude P, Lissek S, Schwenkreis P, Reinersmann A, Frettlöh J, Richter H, Tegenthoff M, Maier C (2011) Bilateral somatosensory cortex disinhibition in Complex Regional Pain Syndrome Type I (CRPS I). Neurology 77(11):1096-101
Mahn F, Hüllemann P, Gockel U, Brosz M, Freynhagen R, Tölle TR, Baron R (2011) Sensory symptom profiles and co-morbidities in painful radiculopathy. PLoS One 6(5):e18018
Riedl V, Valet M, Wöller A, Sorg C, Vogel D, Sprenger T, Boecker H, Wohlschläger AM, Tölle TR (2011) Repeated pain induces adaptations of intrinsic brain activity to reflect past and predict future pain. Neuroimage 57(1):206-13
Uhl I, Krumova EK, Regeniter S, Bär KJ, Norra C, Richter H, Assion HJ, Westermann A, Juckel G, Maier C (2011) Association between wind-up ratio and central serotonergic function in healthy subjects and depressed patients. Neurosci Lett 504(2):176-80
Westermann A, Rönnau AK, Krumova E, Regeniter S, Schwenkreis P, Rolke R, Treede RD, Richter H, Maier C (2011) Pain-associated Mild Sensory Deficits Without Hyperalgesia in Chronic Non-neuropathic Pain. Clin J Pain 27(9):782-9

2010

Baron R, Binder A, Wasner G (2010) Neuropathic pain: diagnosis, pathophysiological mechanisms, and treatment. Lancet Neurol. 9(8):807-19
Baron R, Mahn (2010) Types of topical treatment for peripheral neuropathic pain: Mechanism of action and indications. Schmerz 24(4):317-25
Bachmann CG, Rolke R, Scheidt U, Stadelmann C, Sommer M, Pavlakovic G, Happe S, Treede RD, Paulus W (2010) Thermal hypoaesthesia differentiates secondary restless legs syndrome associated with small fibre neuropathy from primary restless legs syndrome. Brain 133:762-70
Blankenburg M, Boekens H, Hechler T, Maier C, Krumova E, Scherens A, Magerl W, Aksu F, Zernikow B (2010) Reference values for quantitative sensory testing in children and adolescents: developmental and gender differences of somatosensory perception. Pain 149(1):76-88
Gierthmühlen J, Arning P, Binder A, Herzog J, Deuschl G, Wasner G, Baron R (2010) Influence of deep brain stimulation and levodopa on sensory signs in Parkinson's disease. Mov Disord. 25(9):1195-202.
Gierthmühlen J, Schumacher S, Deuschl G, Fritzer E, Klein C, Baron R, Helmchen C (2010) Somatosensory function in asymptomatic Parkin-mutation carriers. Eur J Neurol. 17(3):513-7
Huge V, Lauchart M, Magerl W, Schelling G, Beyer A, Thieme D, Azad SC. (2010) Effects of low-dose intranasal (S)-ketamine in patients with neuropathic pain. Eur J Pain 14:387-94
Magerl W, Krumova EK, Baron R, Tölle T, Treede RD, Maier C (2010) Reference data for quantitative sensory testing (QST): Refined stratification for age and a novel method for statistical comparison of group data. Pain 151(3):598-605
Maier C, Baron R, Tölle TR, Binder A, Birbaumer N, Birklein F, Gierthmühlen J, Flor H, Geber C, Huge V, Krumova EK, Landwehrmeyer GB, Magerl W, Maihöfner C, Richter H, Rolke R, Scherens A, Schwarz A, Sommer C, Tronnier V, Uçeyler N, Valet M, Wasner G, Treede RD (2010) Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): Somatosensory abnormalities in 1236 patients with different neuropathic pain syndromes. Pain 150(3):439-50
Pfab F, Valet M, Sprenger T, Huss-Marp J, Athanasiadis GI, Baurecht HJ, Konstantinow A, Zimmer C, Behrendt H, Ring J, Tölle TR, Darsow U (2010) Temperature modulated histamine-itch in lesional and nonlesional skin in atopic eczema - a combined psychophysical and neuroimaging study. Allergy 65(1):84-94
Rehm SE, Koroschetz J, Gockel U, Brosz M, Freynhagen R, Tölle TR, Baron R (2010) A cross-sectional survey of 3035 patients with fibromyalgia: subgroups of patients with typical comorbidities and sensory symptom profiles. Rheumatology (Oxford) 49(6):1146-52
Reinersmann A, Haarmeyer GS, Blankenburg M, Frettlöh J, Krumova EK, Ocklenburg S, Maier (2010) Left is where the L is right. Significantly delayed reaction time in limb laterality recognition in both CRPS and phantom limb pain patients. Neurosci Lett. 486(3):240-5
Schwenkreis P, Scherens A, Rönnau AK, Höffken O, Tegenthoff M, Maier C. (2010) Cortical disinhibition occurs in chronic neuropathic, but not in chronic nociceptive pain. BMC Neuroscience 11:73
Tölle TR (2010) neuropathischer schmerz - Mit neuer Diagnostik zu einer neuen Klassifikation. neuro aktuell 4:27-28
Wueppenhorst N, Maier C, Frettloeh J, Pennekamp W, Nicolas V (2010) Sensitivity and specificity of three-phase bone scintigraphy in the diagnosis of complex regional pain syndrome (CRPS) of the upper extremity. Clin J. Pain 26(3):182-9

2009

Agostinho C M, Scherens A, Richter H, Schaub C, Rolke, R, Treede R-D, Maier C (2009) Habituation and short-term repeatability of thermal testing in healthy human subjects and patients with chronic non-neuropathic pain. Eur J Pain 13(8):779-85
Baron R, Tölle TR, Gockel U, Brosz M, Freynhagen R (2009) A cross-sectional cohort survey in 2100 patients with painful diabetic neuropathy and postherpetic neuralgia: Differences in demographic data and sensory symptoms. Pain 146(1-2):34-40
Baron R, Tölle TR (2009) Schmerz und QST:..."messen, was messbar ist"... / Pain and QST:.."measure what is measurable".... Schmerz 23(1):5-6
Geber C, Scherens A, Pfau D, Nestler N, Zenz M, Tölle T, Baron R, Treede RD, Maier C (2009) Zertifizierungsrichtlinien für QST-Labore / Procedure for certification of QST laboratories. Der Schmerz 23(1):65-69
Kraus A, Geuze E, Schmahl C, Greffrath W, Treede RD, Bohus M, Vermetten E (2009) Differentiation of pain ratings in combat-related posttraumatic stress disorder. Pain 143(3):179-85
Ludäscher P, Greffrath W, Schmahl C, Kleindienst N, Kraus A, Baumgärtner U, Magerl W, Treede RD, Bohus M (2009) A cross-sectional investigation of discontinuation of self-injury and normalizing pain perception in patients with borderline personality disorder. Acta Psychiatr Scand. 120(1):62-70
Scherens A, Maier C, Haussleiter IS, Schwenkreis P, Vlckova-Moravcova E, Baron R, Sommer C (2009) Painful or painless lower limb dysesthesias are highly predictive of peripheral neuropathy: comparison of different diagnostic modalities. Eur J Pain 13(7):711-8
Schüning J, Scherens A, Haussleiter IS, Schwenkreis P, Krumova EK, Richter H, Maier C (2009) Sensory changes and loss of intraepidermal nerve fibers in painful unilateral nerve injury. Clin J Pain 25(8):683-690
Valet M, Gündel H, Sprenger T, Sorg C, Mühlau M, Zimmer C, Henningsen P, Tölle TR (2009) Patients with pain disorder show gray-matter loss in pain-processing structures: a voxel-based morphometric study. Psychosom Med. 71(1):49-56

2008

Baron R, Tölle TR (2008) Assessment and diagnosis of neuropathic pain. Curr Opin Support Palliat Care 2(1):1-8
Birklein F, Depmeier C, Rolke R, Hansen C, Rautenstrauss B, Prawitt D, Magerl W (2008) A family-based investigation of cold pain tolerance. Pain 138(1):111-8
Freynhagen R, Rolke R, Baron R, Tölle TR, Rutjes AK, Schu S, Treede RD (2008) Pseudoradicular and radicular low-back pain--a disease continuum rather than different entities? Answers from quantitative sensory testing. Pain 135(1-2):65-74.
Geber C, Magerl W, Fondel R, Fechir M, Rolke R, Vogt T, Treede RD, Birklein F (2008) Numbness in clinical and experimental pain--a cross-sectional study exploring the mechanisms of reduced tactile function. Pain 139(1):73-81
Haussleiter IS, Richter H, Scherens A, Schwenkreis P, Tegenthoff M, Maier C (2008) NeuroQuick--a novel bedside test for small fiber neuropathy?. Eur J Pain 12(8):1000-7
Huge V, Lauchart M, Förderreuther S, Kaufhold W, Valet M, Azad SC, Beyer A, Magerl W (2008) Interaction of hyperalgesia and sensory loss in complex regional pain syndrome type I (CRPS I). PLoS One 3(7):e2742
Klauenberg S, Maier C, Assion H J, Hoffmann A, Krumova E, Magerl W, Scherens A, Treede R, Juckel G (2008) Depression and changed pain perception: hints for a central dis-inhibition mechanism. Pain 140(2): 332-43
Klein T, Stahn S, Magerl W, Treede RD (2008) The role of heterosynaptic facilitation in long-term potentiation (LTP) of human pain sensation. Pain 139(3):507-19
Krumova EK, Frettlöh J, Klauenberg S, Richter H, Wasner G, Maier C (2008) Long-term skin temperature measurements - a practical diagnostic tool in complex regional pain syndrome. Pain 140(1):8-22
Maag R, Binder A, Maier C, Scherens A, Toelle T, Treede RD, Baron R (2008) Detection of a characteristic painful neuropathy in Fabry disease: a pilot study. Pain Med. 9(8):1217-23
Tölle TR, Baron R (2008) Dem neuropathischen Schmerz auf der Spur: Standardisierung der QST-Untersuchung schafft Basis für gezielte Therapie. Angewandte Schmerztherapie und Palliativmedizin 1:48-51
Treede RD, Baron R (2008) How to detect a sensory abnormality. Eur J Pain 12:395-396

2007

Baron R, Treede RD (2007) Diagnosis of neuropathic pain. Dtsch Med Wochenschr 132(41):2139-44
Blatow, M., Nennig, E., Durst, A., Sartor, K., Stippich, C. (2007)fMRI reflects functional connectivity of human somatosensory cortex. Neuroimage 37(3):927-36
Geber C, Fondel R, Krämer H, Rolke R, Treede RD, Sommer C, Birklein F (2007) Psychophysics, flare and neurosecretory function in human pain models: Capsaicin vs. electrically evoked pain. J Pain 8:503-514
Hansen N, Klein T, Magerl W, Treede RD (2007) Psychophysical evidence for long-term potentiation of C-fiber and Adelta-fiber pathways in humans by analysis of pain descriptors. J Neurophysiol. 97(3):2559-63
Herweh, C., Kress, B., Rasche, D., Tronnier, V., Tröger, J., Sartor, K., Stippich, C. (2007)Loss of anisotropy in trigeminal neuralgia revealed by diffusion tensor imaging. Neurology 68: 776-778
Klein T, Magerl W, Nickel U, Hopf HC, Sandkühler J, Treede RD (2007) Effects of the NMDA-receptor antagonist ketamine on perceptual correlates of long-term potentiation within the nociceptive system. Neuropharmacology 52(2):655-61
Sinis, N., Haerle, M., Gustin, S., Schwarz, A., Unertl, K., N., Schaller, HE., Birbaumer, N (2007) Memantine treatment of complex regional pain syndrome: a preliminary report of six cases. Clin J Pain 23(3):237-43
Tölle TR, Baron R, Maier C, Treede RD (2007) Neuropathische Schmerzen messbar machen. DZKF 3/4:58-62
Tölle TR, Baron R, Maier C, Romanovic V, Treede RD (2007) German Research Network on Neuropathic Pain (DFNS) - How Multicenter Networking Succeeds with the Development of a Standardized QST Protocol in the Assessment of Neuropathic Pain. Newsletter of the NeuPSIG 10:4-8
Üçeyler N, Tscharke A, Sommer C. (2007) Early cytokine expression in mice after CCI depends on calpain. Brain, Behavior, and Immunity 21:553-560
Üçeyler N, Rogausch JP, Toyka KV, Sommer C. (2007) Differential expression of cytokines in painful and painless neuropathies. Neurology 69:42-49

2006

Baumgärtner U, Buchholz HG, Bellosevich A, Magerl W, Siessmeier T, Rolke R, Höhnemann S, Piel M, Rösch F, Wester HJ, Henriksen G, Stoeter P, Bartenstein P, Treede RD, Schreckenberger M (2006) High opiate receptor binding potential in the human lateral pain system. Neuroimage 30(3):692-9
Diener, H.C., Kronfeld, K. Boewing, G., Lungenhausen, M., Maier, C. Molsberger, A., Tegenthoff, M., Trampisch, H.J., Zenz, M.,Meinert, R. (2006) Efficacy of Acupuncture for the Prophylaxis of Migraine: a Multi-Centre Randomised Controlled Clinical Trial. Lancet Neurol 5:310-316
Freynhagen R, Baron R, Gockel U, Tölle TR (2006) painDETECT: a new screening questionnaire to identify neuropathic components in patients with back pain. Curr Med Res Opin 22(10):1911-1920
Gustin, S. (2006). Behandlungsinduzierte kortikale Reorganisation und Analgesie bei neuropathischen Schmerzen — eine fMRI- und MEG-Studie. Dissertation, Universität Tübingen.
Haußleiter, I., Tegenthoff, M. (2006) Peripher-neurogene Läsionen bei Diabetes mellitus. Akt Neurol 33:543-552
Klein T, Magerl W, Treede RD (2006) Perceptual correlate of nociceptive long-term potentiation (LTP) in humans shares the time course of early-LTP. J Neurophysiol 96(6):3551-5
Krämer HH, Schmidt K, Leis S, Schmelz M, Sommer C, Birklein F (2006) Angiotensin converting enzyme has an inhibitory role in CGRP metabolism in human skin, in vivo. Peptides 27:917-920.
Lang PM, Schober GM, Rolke R, Wagner S, Hilge R, Offenbächer M, Treede RD, Hoffmann U, Irnich D (2006) Sensory neuropathy and signs of central sensitization in patients with peripheral arterial disease. Pain 124(1-2):190-200
McDermott AM, Toelle TR, Rowbotham DJ, Schaefer CP, Dukes EM (2006) The burden of neuropathic pain: results from a cross-sectional survey. Eur J Pain 10(2):127-35
Pleger, B., Ragert, P., Schwenkreis, P.,Foerster, A.F., Wilimzig, C., Dinse, H.R., Nicolas, V., Maier, C., Tegenthoff, M. (2006) Patterns of cortical reorganization parallel impaired tactile discrimination and pain intensity in Complex Regional Pain Syndrome. Neuroimage 32:503 - 510
Rolke R, Baron R, Maier C, Tölle TR, Treede RD, Beyer A, Binder A, Birbaumer N, Birklein F, Bötefür IC, Braune S, Flor H, Huge V, Klug R, Landwehrmeyer GB, Magerl W, Maihöfner C, Rolko C, Schaub C, Scherens A, Sprenger T, Valet M, Wasserka B. (2006) Quantitative Sensory Testing in the German Research Network on Neuropathic Pain (DFNS): Standardized Protocol and Reference Values. Pain 123(3):231-243. Erratum in: Pain (2006) 125(1-2):197
Rolke R, Magerl W, Campbell KA, Schalber C, Caspari S, Birklein F, Treede RD (2006) Quantitative sensory testing: a comprehensive protocol for clinical trials. Eur J Pain 10(1):77-88
Schwarz, A. (2006) Zusammenhang zwischen neuronalen Mechanismen und chronischem Schmerz. Effekt eines NMDA-Rezeptor Antagonist kombiniert mit Morphin: am Beispiel des komplexen regionalen Schmerzsyndroms (CRPS). Dissertation, Universität Tübingen.
Sinis, N., Birbaumer, N., Schwarz, A., Gustin, S., Unertl, K., Schaller, H.E., Haerle, M (2006) Memantine und komplexes regionales Schmerzsyndrom (CRPS): Behandlungseffekte und kortikale Reorganisation. Handchirurgie, Mikrochirurgie, plastische Chirurgie 38(3):164-171
Treede RD (2006) Assessment of pain as an emotion in animals and in humans. Exp Neurol. 197(1):1-3
Üçeyler, N., Valenza, R., Stock, M., Schedel, R., Sprotte, G., Sommer, C. (2006) Reduced anti-inflammatory cytokine levels in patients with chronic widespread pain. Arthritis and Rheumatism 54(8):2656-6

2005

Kress, B., Schindler, M., Rasche, D., Hähnel, S., Tronnier, V., Stippich, C. (2005)MRI volumetry for the preoperative diagnosis of trigeminal neuralgia. European Radiology 15: 1344-1348
Ludwig J, Baron R (2005) Neuropathic pain. MMW Fortschr Med 147(49-50):76-8
Pleger B, Tegenthoff M, Ragert P, Forster AF, Dinse HR, Schwenkreis P, Nicolas V, Maier C. (2005) Sensorimotor retuning in complex regional pain syndrome parallels pain reduction. Ann Neurol 57:425-9.
Schwenkreis, P., Witscher, K., Pleger, B., Malin, J.P., Tegenthoff, M. (2005) The NMDA antagonist memantine affects training induced motor cortex plasticity - a study using transcranial magnetic stimulation. BMC Neuroscience 6:35
Stippich, C., Romanowski, A., Nennig, E., Kress, B., Sartor, K. (2005)Time-efficient localization of the human secondary somatosensory cortex by functional magnetic resonance imaging. Neuroscience Letters 381: 264-268, (IF = 2,019)
Zieglgänsberger W, Berthele A, Tölle TR (2005) Understanding neuropathic pain. CNS Spectr 10(4):298-308

2004

Kress, B., Rasche, D., Fiebach, J., Tronnier, V., Sartor, K., Stippich, C. (2004)MR-Volumetrie des N. trigeminus bei Patienten mit einseitigen Gesichtsschmerzen. Fortschr Röntgenstr 176: 1-5
Pleger, B., Janssen, F., Schwenkreis, P., Völker, B., Maier, C., Tegenthoff, M. (2004) Repetitive transcranial magnetic stimulation of the motor cortex attenuates pain perception in complex regional pain syndrome type I. Neurosci Lett 356:87-90
Pleger B., Tegenthoff M., Schwenkreis P., Janssen F., Ragert P., Dinse, H.R., Voelker B., Zenz, M., Maier, C. (2004) Mean sustained pain levels are linked to hemispherical side-to-side differences of primary somatosensory cortex in the complex regional pain syndrome I. Exp Brain Res 155: 115-119
Stippich, C., Romanowski, A., Nennig, E., Kress, B., Hähnel, S., Sartor, K. (2004) Fully automated localization of the human primary somatosensory cortex in one minute by functional magnetic resonance imaging. Neuroscience Letters 364: 90-93
Treede, R.-D., Handwerker, H.O., Baumgärtner, U., Meyer, R.A., Magerl, W. (2004) Hyperalgesia and Allodynia: Taxonomy, Assessment, and Mechanisms. In: Hyperalgesia: Molecular Mechanisms and Clincial Implications. (progress In Pain Research And Management, Volume 30)
Valet M, Sprenger T, Boecker H, Willoch F, Rummeny E, Conrad B, Erhard P, Tolle TR (2004) Distraction modulates connectivity of the cingulo-frontal cortex and the midbrain during pain--an fMRI analysis. Pain 109(3):399-408

2003

Maier, C., Dertwinkel, R., Mansourian, N., Hosbach, I., Schwenkreis, P., Senne, I., Skipka, G., Zenz, M., Tegenthoff, M. (2003) Efficacy of the NMDA-receptor antagonist memantine in patients with chronic phantom limb pain - Results of a randomized double-blinded, placebo-controlled trial. Pain 103:277-283
Schwenkreis, P., Janssen, F., Rommel, O., Pleger, B., Völker, B., Hosbach, I., Dertwinkel, R., Maier, C., Tegenthoff, M. (2003) Bilateral motor cortex disinhibition in complex regional pain syndrome (CRPS) type I of the hand. Neurology 61:515-519
Schwenkreis, P., Maier, C., Pleger, B., Mansourian, N., Dertwinkel, R., Malin, J.-P., Tegenthoff, M., Zenz, M.(2003) NMDA-mediated mechanisms in cortical excitability changes after limb amputation. Acta Neurol Scand 108:179-184
Schwenkreis, P., Maier, C., Tegenthoff, M. (2003) Fluctuations of motor cortex excitability in pain syndromes. Clin Neurophysiol Suppl 56:394-399
Schwenkreis, P., Pleger, B., Cornelius, B., Weyen, U., Dertwinkel, R., Zenz, M., Malin, J.-P., Tegenthoff, M. (2003) Reorganisation in the ipsilateral motor cortex of patients with lower limb amputation. Neurosci Lett 349:187-190
Schwenkreis, P., Tegenthoff, M. (2003) Therapeutischer Einsatz von Cannabinoiden bei neurologischen Erkrankungen. Schmerz 17:367-373
Wasner G, Schattschneider J, Binder A, Baron R (2003) Complex regional pain syndrome--diagnostic, mechanisms, CNS involvement and therapy. Spinal Cord. 41(2):61-75

2002

Tölle TR, Baron R (2002) Neuropathische Schmerzen: Auf dem Weg vom Mechanismus zur Therapie. MMW-Fortschr. Med. 120:49-59